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Not content with speeding up web browsing and hosting federal data, Amazon Web Services are now helping in the fight against disease. Bezos' crew is donating a chunk of free cloud storage to the 1000 Genomes project, which aims to make it easier for scientists to search for genetic variations linked to diseases. These gene-hunters can also use Amazon's Elastic Cloud Compute service to analyze data and discover patterns, although those functions won't come gratis. The DNA sequences of 1,700 mostly anonymous Homo sapiens from around the world have already been logged, but the project needs another 1,000 samples before it meets statistical requirements. Perhaps a free USB gene sequencer and a Prime subscription might entice fresh volunteers?
Issue Date: March 30, 2012 Proposal Due Date: April 23, 2012 (By close of business day 6:00 p.m.) Anticipated Award Date: May 4, 2012
All Bidders should prepare a response before April 20, 2012.
I. Introduction IREX, (International Research & Exchanges Board), under the scope of G-MEDIA program is seeking proposals from qualified organizations to provide Strategic Planning Services for IREX/G-MEDIA sub-grant recipient Caucasus School of Journalism and Media Management (CSJMM) at the Georgian Institute of Public Affairs (GIPA).
II. Project Requirements
A. Background
About IREX IREX (the International Research & Exchanges Board) is the premier US nonprofit organization specializing in higher education, independent media, Internet development, and civil society programs in the United States, Europe, Eurasia, the Near East, and Asia. Since its founding in 1968, IREX has supported over 15,000 students, scholars, policymakers, business leaders, journalists, and other professionals. IREX serves as a major resource for universities, governments, and the corporate sector in understanding international political, social, economic, and business developments.
The IREX Mission ? Foster democracy in transitioning societies ? Strengthen and help internationalize educational, nongovernmental, and media organizations ? Support the highest-quality research in the social sciences and humanities ? Identify and train the next generation of leaders by working together with universities, nongovernmental organizations, foundations, governments, and corporations
About G-MEDIA Program Funded by USAID, Georgian Media Enhance Democracy, Informed Citizenry and Accountability Program (G-MEDIA) is to improve the public?s access to a range of sources of news and information by developing a more politically balanced, editorially independent, professional and viable media sector that reaches audiences across Georgia through diverse delivery channels. The program seeks to raise the quality and diversity of media content and broaden delivery channels; improve professionalism, including through university journalism education; depoliticize the regulatory environment and strengthen journalists? capacity to address infringements to their rights and breaches of professional ethics; and improve the viability of media outlets. IREX has designed and implemented independent media projects in more than 20 countries across Europe and Eurasia. IREX also publishes the annual Media Sustainability Index (MSI), a valuable tool that analyzes the status and progress of independent media
About CSJMM
IREX/G-MEDIA grant recipient the Caucasus School of Journalism and Media Management (CSJMM) is one of three graduate schools at the Zurab Zhvania Georgian Institute of Public Affairs (GIPA), a non-profit organization concerned with building capacity for effective government, media and civil society. CSJMM currently offers three master?s degree programs: Journalism and Media Management; Journalism and Communication Management and Public Relations. In addition to its degree granting courses, CSJMM trains students and professionals in non-degree programs and trainings.
B. Task Description
IREX is seeking a vendor to facilitate a strategic planning process for the Caucasus School of Journalism and Media Management (CSJMM) that will provide guidance to its management for future decision making and continuous development of its programs and services. The purpose of the strategic planning process will be to assist in (1) determining the local needs which should be addressed; (2) developing a comprehensive and effective 10 year strategic plan.
C. Scope of Services
IREX is seeking a vendor who can assist CSJMM in developing Strategic Plan that will ensure achievement of its mission: to support the development of independent media in the Caucasus by means of educational and training programs in journalism, communication and media management. The school?s philosophy is that journalists? well-grounded in skills to report fairly and accurately and communication specialists ? facilitating a free access to information? will raise the level of journalism where they practice, and will serve the public by providing truthful information and upholding the highest ethical standards of the profession.
IREX is seeking the best strategy that will enable CSJMM to accomplish its mission by (1) exploiting the opportunities and strengths while (2) neutralizing its threats and (3) and correcting (or avoiding) its weaknesses.
IREX recognizes that development of a long range plan should be done as a collaborative process. The strategic planning will include planning, facilitating and evaluating a Planning Retreat with the CSJMM management and staff and, IREX/G-MEDIA representatives to: ? Review and revise, as necessary CSJMM vision and mission statements ? Develop short and long-long term goals and objectives ? Develop key strategies ? Develop key indicators and outcomes that can serve as the basis for performance measurement
The location, cost and event planning of the retreat will be coordinated through IREX/G-MEDIA.
D. Deliverables
Contractor will be responsible for submitting the first draft of the Strategic Plan to IREX and CSJMM for review. After making corrections and revisions to the draft, contractor will make official presentation of the final Strategic Plan to CSJMM and IREX representatives. The dates for submitting the first draft and final Strategic Plan will be specified in the agreement between IREX and Contractor.
IREX anticipates that successful development of a strategic plan will lead to a follow-up project in which vendors will be asked to submit proposals for execution of the plan and direct implementation assistance.
III. Proposal Timeline
A. RFP Release ??March 30
B. Deadline to Submit Questions ??April 9 All questions must be submitted in writing, no later than 6:00 p.m. on April 9, 2012 to the address listed at the end of the document. E-mails are accepted. E-mail subject line must be CSJMM-RFP.
C. Answers to written questions (TENTATIVE) ??April 16
D. Deadline for Proposal Submission ??April 23
E. Review/Approval of Proposal (TENTATIVE) ??May 4
F. Announcement of winner (TENTATIVE) ??May 7
G. Contract signed (TENTATIVE) ??May 14
IV. Proposal Submission A. Proposal must be received no later than the date and time for proposal submission: April 23, 2012 (By 6 p.m.)
B. All correspondence, including the proposals, must be submitted to: Tamar Gabisonia, Senior Journalism Education Officer IREX Georgia 6 Marjanishvili Street Tbilisi 0102, Georgia Email: gmedia@irex.ge
C. Proposal Format
Proposals must be submitted in BOTH hard copy and electronic copy in English before the deadline and should contain the following:
1. Summary of organization?s background and experience in similar projects. Vendor must have minimum of (5) years of experience in facilitating the strategic planning process for an educational institution or similar type of organizations.
2. Name, phone number and address of at least three references from similar contracts.
3. A brief synopsis explaining how the vendor sees CSJMM?s needs and how Vendor plans to meet these needs.
4. A detailed description of the proposed plan to achieve the Scope of Services, Section II, as understood by the vendor and the proposed timeline.
5. Cost. Budget proposal excluding VAT which itemizes all costs required to accomplish the work by task. To itemize salaries, indicate each project team member?s name and title, estimated number of hours to work by each, the hourly wage for each, and each employee?s total salary for the work. Hourly wages submitted shall remain in effect until project completion. If the estimated number of hours worked is exceeded, IREX bears no responsibility to compensate for those hours.
6. Resumes of key staff that will be assigned to the project;
7. Certificate of company registration;
8. Proof that company does not have debts to the tax authorities;
9. Any other pertinent information needed to evaluate proposal.
E. Proposal Condition
A. Contingencies
This request does not commit IREX to award a contract. IREX reserves the right to accept or reject any or all proposals or any part(s) of any or all proposals if IREX determines it is in the best interest of the IREX and CSJMM to do so.
B. Evaluation Process
All proposals will be subject to a standard review process developed by IREX. This includes technical review and evaluation, as well as cost evaluation. The primary consideration shall be the effectiveness of the organization in the delivery of comparable or related services based on demonstrated performance. Performance factors to be evaluated include past experience, delivery date of Strategy Document, cost effectiveness, quality of service, ability to provide complete and through documentation as required by IREX.
Responsive proposals will be evaluated and scored on the following criteria: ? Cost Effectiveness (25%) ? Qualifications of key personnel (25%) ? Quality and appropriateness of the overall methodology and planned activities (30%) ? Organizational capacity ? ability to provide complete and through documentation as required (10%) ? Past references (10%)
C. Incurred Costs
This request does not commit IREX to pay any costs incurred in the preparation of a proposal in response to this request and Proposer agrees that all costs incurred in developing this proposal are the Proposer?s responsibility.
D. Contract Award
Contract will be awarded based on a competitive selection of proposals received.
E. Contract Negotiations
IREX may require the potential contractors selected to participate in negotiations and to submit revisions to pricing, technical information, and/or other items of their proposals as may result from negotiations. The contents of the proposal of the successful Proposer will become contractual obligations, subject to negotiation, and failure to accept these obligations in a contractual agreement may result in cancellation of the award.
FILE - In this Feb. 13, 2012 file photo, a security guard controls the traffic at a container terminal in Tokyo. Weaker than expected factory production in Japan has underscored the fragility of its economic recovery as growth throughout Asia slows. Softening demand for exports led to the first decline in industrial production in the world's third-largest economy in three months, the government said Friday, March 30, though it reported modest improvements in employment and consumer confidence. (AP Photo/Shizuo Kambayashi, File)
FILE - In this Feb. 13, 2012 file photo, a security guard controls the traffic at a container terminal in Tokyo. Weaker than expected factory production in Japan has underscored the fragility of its economic recovery as growth throughout Asia slows. Softening demand for exports led to the first decline in industrial production in the world's third-largest economy in three months, the government said Friday, March 30, though it reported modest improvements in employment and consumer confidence. (AP Photo/Shizuo Kambayashi, File)
FILE - In this Jan. 25, 2012 file photo, a worker pedals a bicycle at a container terminal in Tokyo. Weaker than expected factory production in Japan has underscored the fragility of its economic recovery as growth throughout Asia slows. Softening demand for exports led to the first decline in industrial production in the world's third-largest economy in three months, the government said Friday, March 30, though it reported modest improvements in employment and consumer confidence. (AP Photo/Junji Kurokawa, File)
TOKYO (AP) ? Weaker than expected factory production in Japan has underscored the fragility of its economic recovery as growth throughout Asia slows.
Softening demand for exports led to the first decline in industrial production in the world's third-largest economy in three months, the government said Friday, though it reported modest improvements in employment and consumer confidence.
The news cast a pall over share markets in Asia, already jittery over the pending release Sunday of Chinese economic indicators. The Nikkei 225 index in Tokyo fell 0.3 percent to 10,083.56.
The 1.2 percent decline in industrial output in February was worse than expected and reflected lagging output in the transport equipment, electronics components and machinery industries. Production of cell phones, large passenger cars and liquid crystal devices also weakened, the government said.
"Whether this recent trend will be sustained will depend on the extent of the recovery in Asia," said Masayuki Kichikawa, an economist at Bank of America-Merrill Lynch. "The uncertainty over Chinese data is a very important factor."
The devastating tsunami in March last year ? and a shift of manufacturing overseas to cut costs and reduce damage caused by the strong yen ? plunged Japan's trade account into the red in 2011 for the first time since 1980.
Slowing growth in powerhouse China, the debt crisis in Europe and continued frailty in the U.S. economy have further bit into demand for exports, which remains the strongest driver of growth for Japan.
Despite February's relatively weak number, output is forecast to rise 2.6 percent in March and 0.7 percent in April, as growth accelerates due to a pick up in rebuilding of northeastern regions devastated by last year's disasters.
Kichikawa said he expects the economy to "bottom out" in the second quarter of the year, boosted by strengthening demand for industrial materials such as steel, nonferrous metals and chemicals.
"We think production in Japan is on the uptrend, mainly due to reconstruction demand," he said.
Japan's economy shrank at an annual pace of 2.3 percent in the fourth quarter, also hit by slowing public investment due to political bickering that delayed parliamentary approval for a 12 trillion yen ($156 billion) extra budget for tsunami reconstruction.
The economy contracted last year by 0.9 percent from 2010, when GDP grew a robust 4.4 percent. In 2009, the economy shrank 5.5 percent.
In its latest economic assessment, however, the Organization of Economic Cooperation and Development forecast that Japan's growth would lead that of other major industrial economies in the first quarter, at 3.4 percent.
In other data for February, Japan's consumer price index showed a stronger than expected increase in February of 0.3 percent from the year before, to 99.8. It was up 0.2 percent from January.
Forecasts had been for virtually no change in the index.
Rising costs for fuel and food were the main factors pushing prices higher, the Statistics Bureau reported.
Although rising crude oil prices threaten to further push production prices higher, slight gains in inflation are viewed as a positive for an economy that has been wrestling for years with deflation, or falling prices, which can be a drag on economic growth.
Meanwhile, unemployment fell in February, to 4.5 percent from 4.6 percent in January.
The Ministry of Health, Labor and Welfare reported that the ratio of job offers to job seekers rose to 0.75 in February, up from 0.73 in January. It was the highest figure since November 2008, the ministry said.
Consumer confidence also rose, reflected in a 3.5 percent uptick in retail sales, the largest year-on-year gain since August 2010, the trade ministry reported Thursday.
Demand was also boosted by government subsidies for car purchases, which rose 21.4 percent from a year earlier in February, after jumping 24 percent in January.
___
Follow Elaine Kurtenbach on Twitter: http://www.twitter.com/ekurtenbachsh
Publishing an eBook online is certainly one of the most worthwhile ventures you may undertake an internet to make a few income on the internet. But you must consider what structure your eBook will be in. Choose the incorrect format and you will doom you to ultimately never building a profit, or perhaps not building a profit for too long.
What are formats and precisely what are some of the what you require to consider? A structure is simply what sort of file the information you have will be saved in. On your computer?s desktop are many diverse file sorts, where just about every file form is typically opened by a diverse type of program. For example, you can find plain wording files, usually denoted with a ?.txt? extension, there are ?.doc? information, which are usually opened within Microsoft Word, you can find ?.htm? files, that may be opened simply by any internet browser, and so on. There a wide range of, many different types of formats that are employed by the variety text as well as word control programs your there.
In the same manner, the information you actually present in the eBook needs to be presented to your web audience inside a format they can open up and look. Formats such as .doctor, .txt, .htm (or .html code), .pdf (intended for Adobe?s ubiquitous Acrobat Readers) will have essentially universal readability. However, you must consider not just readability once you make this decision. You must consider piracy as well as copyright infraction. If your eBook is truly standout, with a title such as ?How to produce a million bucks in two weeks by watching TV?, you must know that it will be an excellent target intended for information buccaneers.
Your eBook creation can be your intellectual property or home and needs to get protected as much as possible. Otherwise, individuals can simply pass your e books around online or affix them within emails thus to their friends. You want to ensure that anyone who is looking at your beneficial content possesses legitimately purchased and purchased the right to accomplish that. For this cause, the best option would be to publish the eBook at a many little-known formats that could convert the ebook in to a protected document that can just be opened by the person who has bought it.
There are many programs out there that could convert the eBook in to a secure structure. I can?t even set out to list all, but you want to look for a structure that will alter your eBook into some form of executable (.exe) document that can?t be slashed, copied, or maybe pasted from. Search for ?ebook creation software? or something like that with your favorite Search engine optimization, and adhere to as many links as you desire unless you find the structure you like the best.
It?s up to you to safeguard your content, mainly because certainly no other person is going to do the idea for you!
Until next time <I>Success for your requirements!</I>
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After 12 years it?s finally over. Together, Richard and I toiled over umbrella policies, term life, jewelry appraisals, auto and home insurance. And through it all, I was in good hands. He returned calls quickly, gave me the answers I needed and was always professional. So why after doing a good job for all those years did he lose my business? The answer is simple. While being adequate or even a good salesperson may prevent customers from actively pursuing other business, it does not defend against a another salesperson offering something more than ?good enough.?
So when rookie insurance agent Marcus gave me a call, asked to meet with me, delivered his presentation, showed how he would save me money, and then asked for my business?I jumped!
Because when products are equal and the relationship is purely transactional, the only thing that matters is price.
Let me explain. If I put five soda machines in front of you that dispensed almost the exact product, but one of them was 10% less expensive, which one would you put your money into? Correct! But what if one of them offered a soda that came in a frosty mug, crushed ice, whipped cream (optional for you health nuts), a cherry and a pink umbrella? Wouldn?t that experience be worth the 50 cents extra? Heck yes! And after that liquid ecstasy came out, wouldn?t you tell everybody you knew to run to that machine and buy one? That, my friend, is called referrals.
So this week, I want you to think of your top 10 customers and ask yourself, ?What have I done to create an experience or add value in a way that shows my customers I am irreplaceable?? If the question scares you?GOOD! Because sometime over the next 30 days your competition is coming for your business. NOW is the time to defend it. Because there are few words more painful to the ears of a salesperson than, ?You did a good job, we just decided to give somebody else a try.?
As president of PRECISE Selling, Brian Sullivan, CSP helps improve sales, customer service, negotiations, leadership, and presentation skills through seminars and Internet training programs. To learn more, go to www.preciseselling.com. Or let?s hook up on LinkedIn at tinyurl.com/cynamx6
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Poland?s President Bronislaw Komorowski, right, hugs newly elected German President Joachim Gauck, after he presented him with an original historic Solidarity poster in Warsaw, Poland, on Tuesday March 27, 2012. Words in Polish at the bottom of the poster read: High Noon June 4, 1989. Gauck, 72, is a former East German pro-democracy activist and Lutheran minister who was elected March 18 and inaugurated Friday. German leaders in recent years have sometimes chosen Poland for their first trips abroad, a symbolic gesture stressing the strong alliance that has developed between the nations in the decades since Germany invaded and occupied Poland during World War II. (AP Photo/Czarek Sokolowski)
Poland?s President Bronislaw Komorowski, right, hugs newly elected German President Joachim Gauck, after he presented him with an original historic Solidarity poster in Warsaw, Poland, on Tuesday March 27, 2012. Words in Polish at the bottom of the poster read: High Noon June 4, 1989. Gauck, 72, is a former East German pro-democracy activist and Lutheran minister who was elected March 18 and inaugurated Friday. German leaders in recent years have sometimes chosen Poland for their first trips abroad, a symbolic gesture stressing the strong alliance that has developed between the nations in the decades since Germany invaded and occupied Poland during World War II. (AP Photo/Czarek Sokolowski)
Poland's President Bronislaw Komorowski, right, hands over an original historic Solidarity poster to the new German President Joachim Gauck, in Warsaw, Poland, on Tuesday March 27, 2012. Gauck, 72, is a former East German pro-democracy activist and Lutheran minister who was elected March 18 and inaugurated Friday. German leaders in recent years have sometimes chosen Poland for their first trips abroad, a symbolic gesture stressing the strong alliance that has developed between the nations in the decades since Germany invaded and occupied Poland during World War II. (AP Photo/Czarek Sokolowski)
Newly elected Germany's President Joachim Gauck speaks to the media during his visit to Warsaw, Poland, Tuesday, March 27, 2012. In front a German flag symbol, behind Gauck the Polish flag. (AP Photo/Czarek Sokolowski)
Newly elected Germany's President Joachim Gauck speaks to the media during his vist to Warsaw, Poland, Tuesday, March 27, 2012. (AP Photo/Czarek Sokolowski)
Poland's President Bronislaw Komorowski, right, shakes hands with the new German President Joachim Gauck. as he presents him an original historic Solidarity poster in Warsaw, Poland, on Tuesday March 27, 2012. (AP Photo/Czarek Sokolowski)
WARSAW, Poland (AP) ? Germany's new president praised Poland as a land of freedom and expressed remorse over the cruelty inflicted by Germany on the country during World War II, in a first foreign visit heavy with symbolism.
Joachim Gauck's words of reconciliation and warmth for the eastern neighbor were made Tuesday in Warsaw four days after he was inaugurated into a role that carries more moral authority than real power.
Trips to Poland by German leaders always carry a degree of symbolic and emotional weight due to persisting memories of the war. In recent years, some German leaders have made their first visits abroad to Poland, though France remains a common destination too.
Though the two countries are strong allies today, many older Poles remain bitter, and negative stereotypes on both sides still exist. Gauck, who is 72, noted that he remained conscious of German "guilt."
"It's been a big joy for me to be received here with an openness and warmth that I would never take for granted," Gauck said. "I am an older German, born during the war and deeply remember the changing history and the brutality of Germans before my time toward Poland."
A former Lutheran pastor and democracy activist in East Germany, Gauck also spoke of the inspiration Poland was for him during the 1980s, when the Solidarity movement led by Lech Walesa struggled for freedom in Poland.
"For me, Poland is the European country of freedom," Gauck said during a joint news conference with Polish President Bronislaw Komorowski. He said that while there were political considerations for coming to Poland first, the decision above all "came from the heart."
Komorowski, who was also an anti-communist dissident, gave Gauck an original historic poster of Solidarity.
Gauck appeared surprised and moved by the gift, and said he already has the same poster hanging in his home. He said the new one would be displayed in his office.
He thanked Komorowski, and the leaders shook hands and then hugged.
Poland and Germany today belong to the European Union and NATO and are major trading partners. The presidents said they discussed ways to deepen their ties further, for instance through youth initiatives or rock concerts ? with Gauck saying he would attend such a concert despite his age.
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Modded PS3 controller is the controls that are used in the play station games. This is a game that is known for the ability of the user and the people playing the game to have fun and also enjoy. The controls are easy to use and above all are flexible. Flexibility of the control is important in any game. modded ps3 controller
The gaming community is one that keeps growing with the introduction of new games in the market. Gaming companies therefore have a way to make money through the provision of the gaming facilities that are required. Each game will come with its own set of gaming needs.
There are various types of controls. There is the basic control kit, the custom kit and the programmable kit. The programmable one is for the gamer who would like to change the way they play the games. They make the controls more user friendly to them.
Online shops are the best for any type of shopping. One is able to order to the controls that they feel they can use comfortably. They also get to choose the color and the design that they would like the control delivered in. This is all done online.
Verifying the authenticity of any controller pads is a must. It is the only way to avoid experiencing problems with the pads once one has started playing. Faulty pads may cost more in the long run. Authentic products will last longer than any other products.
Modded PS3 controllers are just a way to enable the gaming community have fun playing games. Games are not for children or teenagers alone. There are games that the adult male would have fun with and not feel child like when playing. Innovations have made this possible. Each gamer has something to enjoy.
After speaking to her PR team and being told what to do thinking about the act of violence perpetrated against her on a Los Angeles red carpet last week, Kim Kardashian has decided to press charges against the woman who threw flour all over her.
She will reportedly contact law enforcement officials over the next few days and take the appropriate steps.
In response to this decision, PETA has gone on the attack against Kardashian. That lame organization denies involvement in the act, but has released a statement that reads:
If she presses charges, at least people will be constantly reminded of her selfish, callous disregard for the cruel deaths that she causes by wearing fur.
How much better it would be if she decided to evolve and enhance her image by donating her vulgar furs and exotic-animal skins to the homeless. The activist acted from the heart, something Kim doesn't seem to have. If anything, Kim should get a life, the very thing that she denies animals.
What do you think? Should Kardashian press charges against her attacker?
Cryoablation therapy spot-freezes breast cancer tumorsPublic release date: 26-Mar-2012 [ | E-mail | Share ]
Contact: Ellen Acconcia eacconcia@sirweb.org 703-460-5582 Society of Interventional Radiology
Icy interventional radiology treatment controls metastatic breast cancer with less pain and no major complications
Individuals fighting metastatic breast cancer, where the disease has progressed to other areas of the body, may finally have another weapon in their arsenal: percutaneous cryoablation. The cancer treatment could potentially be used as a last line of defense to halt individual spots of remaining metastatic disease by freezing and destroying tumors, say researchers presenting a study at the Society of Interventional Radiology's 37th Annual Scientific Meeting in San Francisco, Calif.
"Breast cancer is the most common cancer in women, causing 1 million new cases and killing 370,000 people worldwide each year, and approximately 10,000 to 15,000 cases of stage IV breast cancer occur in the United States annually," said Peter J. Littrup, M.D., director of imaging core and radiology research at the Karmanos Cancer Institute in Detroit, Mich. "If you envision cancer treatment as a three-legged stool: you have radiation therapy, surgery and chemotherapy. When you get to the point of metastatic disease, you end up managing people whose treatments have failed. We are introducing the fourth leg on the stool of cancer care: tumor ablation."
"Stage IV metastatic breast cancer means tumors have spread widely from the primary tumors in the breasts to other tissues of the body. This stage of disease is currently viewed as incurable and associated with a low rate of survival. While less than 5 percent of those are initially diagnosed with metastases, an estimated 25 to 40 percent will develop these additional tumors, which are notoriously difficult to wipe out, even with multiple forms and repeated rounds of treatment," said Littrup. "At this point, treatments are considered palliativewith the intent to keep metastases at bay while hopefully providing individuals more time and improved quality of life, rather than a complete cure. But after mastectomy, radiation and chemotherapy, it is time to try something new," he added.
"Why should people have to keep changing from one expensive chemo drug to another when there are just a few remaining spots?" said Littrup. "Cryoablation could offer these individuals a new treatment option," he added.
Most commonly, these metastatic tumors take up residence in the liver; the lungs and pleuraa thin layer of tissue that wraps around the lungs; the soft tissues; the kidneys; and in the bone. Percutaneous cryoablation essentially comes in and cleans up single tumors that persist after first and follow-up treatment. This interventional radiology procedure involves the use of tiny probes inserted with a catheter from a small cut in the skin and then guided to the tumors, at which point pressurized argon gas is introduced, turning the tumor into a ball of ice, effectively killing the cancerous tissue. Helium gas is then pumped in to help release the needle. This process is guided by medical imaging such as computed tomography (CT) or ultrasound, which capture the procedure by picking up the distinct densities between the normal tissues and frozen cancer tissue; the ice ball can be seen as a clearly defined darker mass, as it has a lower density than the surrounding tissue. This treatment could provide a valuable alternative to other spot-therapies because there is minimal damage to surrounding healthy tissues and the side effects and recovery time are dramatically reduced when compared to those of other therapies, said Littrup.
"Cryoablation as a targeted therapy is beneficial because it can significantly reduce discomfort and incidence of disease," said Littrup. "It's a much better option, we think, than surgery, especially since many metastatic patients are not candidates for surgery, and it may potentially lead to longer survival if it coincides with more data concerning primary metastases in other regions of the body," he said.
For the study, a total of eight people with nine tumors received percutaneous cryoablation procedures guided with CT, ultrasound or a combination of both methods. Six of the eight subjects had formerly undergone at least a single mastectomy prior to treatment with percutaneous cryoablation. The secondary tumors of these people were found in the liver, lung and kidney. There were no serious complications and all procedures were considered successful. All individual tumors remaining in the body were found and the local cancer did not recur. The median overall survival for those in the study was 46 months, and 25 percent survived past the five-year anniversary of treatment. Researchers conclude that percutaneous cryoablation could potentially be used as an effective alternative treatment for metastatic breast cancer, especially with the promising results they have had with many more patients suffering from other types of metastatic disease.
"This therapy provides a minimal rate of cancer recurrence and no major complications, making these ice balls ideal for targeting metastatic tumors that are limited in number and location," said Littrup. "This is a preliminary study, and at this point we're hoping that the evidence could be a stepping stone for a bigger study to look at more patients. If we can get more data that supports percutaneous cryoablation for metastatic breast cancer, it could be a huge finding," he added.
###
More information about the Society of Interventional Radiology, interventional radiologists and minimally invasive treatments can be found online at www.SIRweb.org.
Abstract 272: "Percutaneous Cryoablation of Metastatic Breast Cancer: Initial Survival, Local Control and Cost Observations," H.J. Bang, B.P. Currier, J. Kuo, Radiology, Wayne State University, Detroit, Mich.; P.J. Littrup, H.D. Aoun, B. Adam, radiology, Karmanos Cancer Institute, Detroit, Mich.; L. Klein, University of Michigan, Ann Arbor, Mich.; D.J. Goodrich, University of California-Los Angeles, Los Angeles, Calif. SIR 37th Annual Scientific Meeting, March 24-29, 2012. This abstract can be found at www.JVIR.org.
About the Society of Interventional Radiology
Interventional radiologists are physicians who specialize in minimally invasive, targeted treatments. They offer the most in-depth knowledge of the least invasive treatments available coupled with diagnostic and clinical experience across all specialties. They use X-ray, MRI and other imaging to advance a catheter in the body, such as in an artery, to treat at the source of the disease internally. As the inventors of angioplasty and the catheter-delivered stent, which were first used in the legs to treat peripheral arterial disease, interventional radiologists pioneered minimally invasive modern medicine.
Today, interventional oncology is a growing specialty area of interventional radiology. Interventional radiologists can deliver treatments for cancer directly to the tumor without significant side effects or damage to nearby normal tissue. Many conditions that once required surgery can be treated less invasively by interventional radiologists. Interventional radiology treatments offer less risk, less pain and less recovery time compared to open surgery. Visit www.SIRweb.org.
The Society of Interventional Radiology is holding its 37th Annual Scientific Meeting March 24-29 at Moscone Center, San Francisco, Calif. The theme of the meeting is "IR Evidence," chosen to reflect interventional radiology's gathering, presenting and discussing results of care-changing investigations.
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Cryoablation therapy spot-freezes breast cancer tumorsPublic release date: 26-Mar-2012 [ | E-mail | Share ]
Contact: Ellen Acconcia eacconcia@sirweb.org 703-460-5582 Society of Interventional Radiology
Icy interventional radiology treatment controls metastatic breast cancer with less pain and no major complications
Individuals fighting metastatic breast cancer, where the disease has progressed to other areas of the body, may finally have another weapon in their arsenal: percutaneous cryoablation. The cancer treatment could potentially be used as a last line of defense to halt individual spots of remaining metastatic disease by freezing and destroying tumors, say researchers presenting a study at the Society of Interventional Radiology's 37th Annual Scientific Meeting in San Francisco, Calif.
"Breast cancer is the most common cancer in women, causing 1 million new cases and killing 370,000 people worldwide each year, and approximately 10,000 to 15,000 cases of stage IV breast cancer occur in the United States annually," said Peter J. Littrup, M.D., director of imaging core and radiology research at the Karmanos Cancer Institute in Detroit, Mich. "If you envision cancer treatment as a three-legged stool: you have radiation therapy, surgery and chemotherapy. When you get to the point of metastatic disease, you end up managing people whose treatments have failed. We are introducing the fourth leg on the stool of cancer care: tumor ablation."
"Stage IV metastatic breast cancer means tumors have spread widely from the primary tumors in the breasts to other tissues of the body. This stage of disease is currently viewed as incurable and associated with a low rate of survival. While less than 5 percent of those are initially diagnosed with metastases, an estimated 25 to 40 percent will develop these additional tumors, which are notoriously difficult to wipe out, even with multiple forms and repeated rounds of treatment," said Littrup. "At this point, treatments are considered palliativewith the intent to keep metastases at bay while hopefully providing individuals more time and improved quality of life, rather than a complete cure. But after mastectomy, radiation and chemotherapy, it is time to try something new," he added.
"Why should people have to keep changing from one expensive chemo drug to another when there are just a few remaining spots?" said Littrup. "Cryoablation could offer these individuals a new treatment option," he added.
Most commonly, these metastatic tumors take up residence in the liver; the lungs and pleuraa thin layer of tissue that wraps around the lungs; the soft tissues; the kidneys; and in the bone. Percutaneous cryoablation essentially comes in and cleans up single tumors that persist after first and follow-up treatment. This interventional radiology procedure involves the use of tiny probes inserted with a catheter from a small cut in the skin and then guided to the tumors, at which point pressurized argon gas is introduced, turning the tumor into a ball of ice, effectively killing the cancerous tissue. Helium gas is then pumped in to help release the needle. This process is guided by medical imaging such as computed tomography (CT) or ultrasound, which capture the procedure by picking up the distinct densities between the normal tissues and frozen cancer tissue; the ice ball can be seen as a clearly defined darker mass, as it has a lower density than the surrounding tissue. This treatment could provide a valuable alternative to other spot-therapies because there is minimal damage to surrounding healthy tissues and the side effects and recovery time are dramatically reduced when compared to those of other therapies, said Littrup.
"Cryoablation as a targeted therapy is beneficial because it can significantly reduce discomfort and incidence of disease," said Littrup. "It's a much better option, we think, than surgery, especially since many metastatic patients are not candidates for surgery, and it may potentially lead to longer survival if it coincides with more data concerning primary metastases in other regions of the body," he said.
For the study, a total of eight people with nine tumors received percutaneous cryoablation procedures guided with CT, ultrasound or a combination of both methods. Six of the eight subjects had formerly undergone at least a single mastectomy prior to treatment with percutaneous cryoablation. The secondary tumors of these people were found in the liver, lung and kidney. There were no serious complications and all procedures were considered successful. All individual tumors remaining in the body were found and the local cancer did not recur. The median overall survival for those in the study was 46 months, and 25 percent survived past the five-year anniversary of treatment. Researchers conclude that percutaneous cryoablation could potentially be used as an effective alternative treatment for metastatic breast cancer, especially with the promising results they have had with many more patients suffering from other types of metastatic disease.
"This therapy provides a minimal rate of cancer recurrence and no major complications, making these ice balls ideal for targeting metastatic tumors that are limited in number and location," said Littrup. "This is a preliminary study, and at this point we're hoping that the evidence could be a stepping stone for a bigger study to look at more patients. If we can get more data that supports percutaneous cryoablation for metastatic breast cancer, it could be a huge finding," he added.
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More information about the Society of Interventional Radiology, interventional radiologists and minimally invasive treatments can be found online at www.SIRweb.org.
Abstract 272: "Percutaneous Cryoablation of Metastatic Breast Cancer: Initial Survival, Local Control and Cost Observations," H.J. Bang, B.P. Currier, J. Kuo, Radiology, Wayne State University, Detroit, Mich.; P.J. Littrup, H.D. Aoun, B. Adam, radiology, Karmanos Cancer Institute, Detroit, Mich.; L. Klein, University of Michigan, Ann Arbor, Mich.; D.J. Goodrich, University of California-Los Angeles, Los Angeles, Calif. SIR 37th Annual Scientific Meeting, March 24-29, 2012. This abstract can be found at www.JVIR.org.
About the Society of Interventional Radiology
Interventional radiologists are physicians who specialize in minimally invasive, targeted treatments. They offer the most in-depth knowledge of the least invasive treatments available coupled with diagnostic and clinical experience across all specialties. They use X-ray, MRI and other imaging to advance a catheter in the body, such as in an artery, to treat at the source of the disease internally. As the inventors of angioplasty and the catheter-delivered stent, which were first used in the legs to treat peripheral arterial disease, interventional radiologists pioneered minimally invasive modern medicine.
Today, interventional oncology is a growing specialty area of interventional radiology. Interventional radiologists can deliver treatments for cancer directly to the tumor without significant side effects or damage to nearby normal tissue. Many conditions that once required surgery can be treated less invasively by interventional radiologists. Interventional radiology treatments offer less risk, less pain and less recovery time compared to open surgery. Visit www.SIRweb.org.
The Society of Interventional Radiology is holding its 37th Annual Scientific Meeting March 24-29 at Moscone Center, San Francisco, Calif. The theme of the meeting is "IR Evidence," chosen to reflect interventional radiology's gathering, presenting and discussing results of care-changing investigations.
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The Southern Africa Food & Drink Report features Business Monitor International (BMI)?s market assessment and independent forecasts to end-2016 for food and drink expenditure, consumption, sales, and imports/exports, and for the mass grocery retail sector. The report also includes analyses of major regulatory developments, the background macroeconomic outlook, and competitive landscape comparing national and multinational companies by leading products and services, sales, investments, partners and expansion strategies.?http://www.bharatbook.com/market-researc?
BMI?s Southern Africa Food & Drink Report provides industry professionals and strategists, sector analysts, business investors, trade associations and regulatory bodies with independent forecasts and competitive intelligence on the food and drink industry, and the mass grocery retail market in Angola, Botswana, Mozambique, Namibia and Zambia. Market Research Companies
Key Benefits * Benchmark BMI?s independent food and drink industry forecasts to end-2016 on Southern Africa to test other views ? a key input for successful budgeting and strategic business planning in the Southern Africa food and drink market. * Target business opportunities and risks in Southern Africa through our reviews of latest industry trends, regulatory changes, and major deals, projects and investments. * Exploit latest competitive intelligence on your competitors, partners and clients via our Company Profiles (inc. SWOTs, KPIs and latest activity) and Competitive Landscape Tables.
Executive Summary Summary of BMI?s key industry forecasts, and views, covering food and drink manufacturing and consumption and the retail market.
Business Environment Ratings BMI?s Food & Drink Business Environment Ratings provide a country-comparative Risk-Reward Ratings index aimed at investors, food and drink manufacturers and mass grocery retailers.
The ratings methodology makes sophisticated use of over 40 industry, economic and demographic data points.
Industry SWOT Analysis Analysis of the major Strengths, Weaknesses, Opportunities and Threats within the food, drink and mass grocery retail sectors, and within the broader political, economic and business environment.
Food Forecasts To End-2016 Divided into three sections, BMI?s food chapter provides insight into a market?s food industry, centred on a forecast to end-2016 for the sector. The chapter includes the following elements:
Industry Forecast Scenario ? Historical data series and forecasts to end-2016 for growth of key indicators within a market?s food industry. Including consumption, food consumption as % of GDP, canned food sales, confectionery sales and food and drink imports and exports, among others.
Industry Developments ? A summary of corporate developments, including news on M&As, FDI, expansions, closures and financial results, in addition to analysis and explanation of the latest industry events and how these could influence further investment.
Market Overview ? An overview of the structure of the market, introducing the key players and discussing underlying trends.
Drink Forecasts To End-2016 Segmented the same way as BMI?s food chapter, the drink section provides insight into the market?s drink industry, centred on a forecast to end-2016 for the sector. Forecast indicators include alcoholic and soft drink sales by value, volume and sub-sector and tea and coffee sales, among others.
Mass Grocery Retail Forecasts To End-2016 Segmented the same way as BMI?s food and drink chapters, the mass grocery retail section provides insight into a market?s grocery retail industry, centred on a forecast to end-2016 for the sector. Forecast indicators include mass grocery retail sales by format (including supermarkets, hypermarkets, convenience and discount stores) and a breakdown for the organised retail sector versus the traditional sector, among others.
For more information kindly visit : Southern Africa Food and Drink Report
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Bharat Book Bureau Tel: +91 22 27810772 / 27810773 Fax: + 91 22 27812290 Email: ?info at bharatbook.com Website:?www.bharatbook.com Follow us on twitter:?http://twitter.com/#!/Sandhya3B
Acronym overload alert! This Friday, the GRS/GSP (Graduate Students for Publishing?it?s new, and promises to be sweet) are teaming forces and budgets to bring you lots of food and beverages and literary sensations beyond your wildest dreams. The food/drink selection will be some old and some new. If you?ve never been to a GRS, this is the one to see. If you?re knee deep in thesis-work, this is the break you?ve been yearning for. And if your a GRS regular, we?ve got everything you love, and more. Here are the reader bios.
Grace Schauer?is a music note printed in small type to indicate that she is melodically and harmonically nonessential. ?She was born in 1815 and wrote her first poems shortly after. ?Having stretched a two-year program past all decency and reason, she will graduate in May.
After his undergraduate years at Baker University,?Keith Gaboury?earned a MA inEnglish / creative writing at San Francisco State University. He?s currently attendingEmerson College?s MFA program. Keith will be reading from a collection of ekphrasticpoetry, outer space-theme poems and a persona poem in the voice of an animal. Come tothe GRS and guess who is speaking!
Kelly Addams?is a first year MFA student. She will be reading fiction.
Andy Dost?is a second year in the publishing program, taking odd jobs as they come. He sticks to a need-to-know clause on all contracts and will not pry into business practices or blow whistles. Odd jobs include writing nonfiction, editing, coding, high-security exchanges of goods, and otherwise. Whistle-making companies need not apply.
Nicole Miller?is a final year MFA student in fiction, who is currently writing a novel and a memoir. ?She grew up in New York city, near Washington Square, which is also the setting of the novel excerpt she will be reading at the GRS. ?For recent writing online, you can check out her article, ?Cavafy in Paradise?, on translating the Alexandrian poet C.P. Cavafy at the House of Literature in Paros, Greece, last summer:http://www.emerson.edu/academics/academic-services/graduate-studies/department-news/creative-writing-student-attends-translation-workshop-greece
Lauren Johnson:?Due to some confusion over where in the world is the real Lauren Johnson, we?ve been delayed in obtaining a bio. It?s coming soon!
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Public release date: 26-Mar-2012
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